Phylogenomics An Introduction /

• Κύριος συγγραφέας: Bleidorn, Christoph (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Θέματα: Life sciences.; Human genetics.; Bioinformatics.; Evolutionary biology.; Microbial genetics.; Microbial genomics.; Animal genetics.; Life Sciences.; Evolutionary Biology.; Human Genetics.; Microbial Genetics and Genomics.; Animal Genetics and Genomics.

This unique textbook provides a clear and concise overview of the key principles of the complex field of phylogenomics, with a particular focus on sequencing technologies that are crucial to studying and understanding interrelations in evolutionary genomics. It includes chapters dedicated to the ana...

Πίνακας περιεχομένων:

• 1. Genomes
• 01.1 Prokaryotes vs. Eukaryotes
• 01.2 Genome Structure
• 01.3 Genome Sizes
• 01.4 Human Genome and Ancient DNA (Neandertaler, Denisova)
• 2. Genomes of Organelles
• 02.1 Mitochondria
• 02.2 Plastids
• 02.3 Outlook Obligate Endosymbionts
• 3. Transcriptomes
• 03.1 mRNA
• 03.2 Transcripts
• 03.3 Expression Level
• 03.4 Alternative Splicing
• 4. Sequencing Techniques
• 04.1 Sanger
• 04.2 Illumina
• 04.3 454
• 04.4 PacBio
• 04.5 Outlook Nanopore Sequencing
• 5. Genome Sequencing Strategies
• 05.1 Whole Genome Shotgun
• 05.2 RADseq
• 05.3 Target Enrichment
• 05.4 RNAseq
• 6. Assembly and Mapping
• 06.1 Assembling Strategies (kmer vs OLC)
• 06.2 Data Quality and Filtering
• 06.3 Re-Sequencing and Mapping
• 06.4 De novo Assembly Genome
• 06.5 De novo Assembly Transcriptome
• 7. Locating Genes
• 07.1 Orthology vs. Paralogy
• 07.2 BLAST and Successors
• 07.3 Hidden Markov Profile
• 07.4 Ortholog Conjecture
• 8. Alignment
• 08.1 Alignment Strategies
• 08.2 Alignment Masking
• 9. Phylogenetic Analysis
• 09.1 Distance Measurements
• 09.2 Maximum Parsimony
• 09.3 Maximum Likelihood
• 09.4 Bayesian Inference
• 09.5 Supermatrix vs. Single Gene Analysis (Gene Trees vs. Species Trees)
• 10. Systematic Errors in phylogenetic Analysis
• 10.1 Prediction: Evolutionary Models
• 10.2 Heterogenity Nucleotide/Amino Acid-Composition
• 10.3 Variation of substitution rate between the lines
• 10.4 Variation of substitution rate over time
• 10.5 New Approaches to Correct systematic Errors
• 11. Genome-wide Characteristics
• 11.1 Gene Order
• 11.2 Mobile Elements
• 11.3 microRNAs
• 11.4 Differences in the genetic code
• 12. Index
• 13. References.