Patient-Derived Xenograft Models of Human Cancer

• Corporate Author: SpringerLink (Online service)
• Other Authors: Wang, Yuzhuo (Editor), Lin, Dong (Editor), Gout, Peter W. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Humana Press, 2017.
• Series: Molecular and Translational Medicine,
• Subjects: Medicine.; Oncology.; Medicine & Public Health.

This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current appl...

Table of Contents:

• Introduction
• History and Evolution of PDX Cancer Models
• Establishment and Characterization of PDX Models
• Methods of Generating PDX Models
• Fidelity and Stability of PDX Models
• Applications of PDX Models
• Studies of Cancer Heterogeneity
• PDX and Cancer Stem Cells
• Modeling Cancer Metastasis
• Modeling Drug Resistance
• PDX and Biomarker Development
• PDX and Preclinical Drug Screening
• Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine
• Epilogue
• Future Perspective.