Patient-Derived Xenograft Models of Human Cancer

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Wang, Yuzhuo (Επιμελητής έκδοσης), Lin, Dong (Επιμελητής έκδοσης), Gout, Peter W. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Humana Press, 2017.
• Σειρά: Molecular and Translational Medicine,
• Θέματα: Medicine.; Oncology.; Medicine & Public Health.

This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current appl...

Πίνακας περιεχομένων:

• Introduction
• History and Evolution of PDX Cancer Models
• Establishment and Characterization of PDX Models
• Methods of Generating PDX Models
• Fidelity and Stability of PDX Models
• Applications of PDX Models
• Studies of Cancer Heterogeneity
• PDX and Cancer Stem Cells
• Modeling Cancer Metastasis
• Modeling Drug Resistance
• PDX and Biomarker Development
• PDX and Preclinical Drug Screening
• Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine
• Epilogue
• Future Perspective.