Chemical Mixtures and Combined Chemical and Nonchemical Stressors Exposure, Toxicity, Analysis, and Risk /

Exposure to multiple chemical and nonchemical stressors is the rule, not the exception. Nevertheless, it continues to be a significant challenge in toxicology and risk assessment to thoroughly take mixtures into account. In this book, both basic and advanced concepts for considering mixtures are dis...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Rider, Cynthia V. (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Simmons, Jane Ellen (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2018.
Έκδοση:1st ed. 2018.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
Πίνακας περιεχομένων:
  • Introduction
  • Combined exposures.-Measuring combined exposures
  • Modeling complex exposures.-Prioritizing mixtures for study
  • Environment-Wide Association Studies
  • Biogeographical analysis of chemical co-occurrence
  • Combining exposure and toxicity information to develop logical groupings for assessment
  • Maximum Cumulative Ratio for deciding when to assess mixtures
  • Establishing the "no interaction" baseline
  • Dose addition models
  • Response addition
  • Integrated addition
  • Mixture statistics - comparing predicted to observed
  • Cumulative Risk Assessment
  • Deciding which approach to use
  • Component-based approaches
  • Sufficient similarity of whole mixtures
  • Other whole mixtures approaches
  • Assessing interactions
  • Likelihood and examples of chemical interactions
  • PBPK modeling of chemical interactions
  • Adding interactions to cumulative risk assessment
  • Consideration of nonchemical stressors
  • Toxicity and interactions of physical and chemical stressors
  • Psychosocial and chemical stressors
  • Adding nonchemical stressors to cumulative risk assessments
  • Disease-based risk assessment
  • Community-based risk assessment.