Chemical Mixtures and Combined Chemical and Nonchemical Stressors Exposure, Toxicity, Analysis, and Risk /
Exposure to multiple chemical and nonchemical stressors is the rule, not the exception. Nevertheless, it continues to be a significant challenge in toxicology and risk assessment to thoroughly take mixtures into account. In this book, both basic and advanced concepts for considering mixtures are dis...
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| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
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Cham :
Springer International Publishing : Imprint: Springer,
2018.
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| Edition: | 1st ed. 2018. |
| Subjects: | |
| Online Access: | Full Text via HEAL-Link |
Table of Contents:
- Introduction
- Combined exposures.-Measuring combined exposures
- Modeling complex exposures.-Prioritizing mixtures for study
- Environment-Wide Association Studies
- Biogeographical analysis of chemical co-occurrence
- Combining exposure and toxicity information to develop logical groupings for assessment
- Maximum Cumulative Ratio for deciding when to assess mixtures
- Establishing the "no interaction" baseline
- Dose addition models
- Response addition
- Integrated addition
- Mixture statistics - comparing predicted to observed
- Cumulative Risk Assessment
- Deciding which approach to use
- Component-based approaches
- Sufficient similarity of whole mixtures
- Other whole mixtures approaches
- Assessing interactions
- Likelihood and examples of chemical interactions
- PBPK modeling of chemical interactions
- Adding interactions to cumulative risk assessment
- Consideration of nonchemical stressors
- Toxicity and interactions of physical and chemical stressors
- Psychosocial and chemical stressors
- Adding nonchemical stressors to cumulative risk assessments
- Disease-based risk assessment
- Community-based risk assessment.
