Cell Division Machinery and Disease

• Corporate Author: SpringerLink (Online service)
• Other Authors: Gotta, Monica (Editor), Meraldi, Patrick (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Series: Advances in Experimental Medicine and Biology, 1002
• Subjects: Life sciences.; Cancer research.; Cell cycle.; Cell physiology.; Life Sciences.; Cell Cycle Analysis.; Cell Physiology.; Cancer Research.

This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link...

Table of Contents:

• 1.Meiotic divisions: no place for gender equality
• 2.Consequences of centrosome dysfunction during brain development
• 3.Dividing with extra centrosomes: a double edged sword for cancer cells
• 4.Kinetochore malfunction in human pathologies
• 5.The elephant in the room: the role of microtubules in cancer
• 6.Clinical development of anti-mitotic drugs in cancer
• 7.Mitotic dysfunction associated with aging hallmarks
• 8.Unbalanced Growth, Senescence and Aging
• 9.The spindle orientation machinery beyond mitosis: when cell specialization demands polarization.