The Structural Basis of Arrestin Functions
This volume summarizes our current understanding of the structural basis of the functions of arrestin family of proteins. Arrestins were first discovered as key players in the desensitization of G protein-coupled receptors (GPCRs). Recent studies showed that arrestins are important signal transducer...
| Συγγραφή απο Οργανισμό/Αρχή: | |
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| Άλλοι συγγραφείς: | |
| Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Cham :
Springer International Publishing : Imprint: Springer,
2017.
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| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Arrestins: discovery of the family and functional role of conformational flexibility
- Overview of arrestin-mediated signaling with receptors and non-receptor binding partners
- Initial crystallographic studies of visual arrestin: insights and perspectives
- Structural basis for b-arrestins in GPCR trafficking
- Arrestin-3: the structural basis of lower receptor selectivity
- Phosphate sensor and construction of phosphorylation-independent arrestins
- Comprehensive analysis of the role of arrestin residues in receptor binding
- How arrestin recognizes and binds active GPCRs
- Localization of conformational dynamics of arrestins by HDX-MS
- GPCR footprint on arrestins and manipulation of receptor specificity
- The structure of the polar core mutant R175E and its functional implications
- Active conformations of arrestins: expected and unexpected changes
- The arrestin-receptor complex: exciting answers and new questions
- Scaffolding c-Jun N-terminal kinase cascades: mechanistic insights from the reconstituted arrestin-JNK cascades
- Arrestin-dependent ERK activation and its disruption
- The functional role of the conformational changes in arrestin upon activation
- Is signaling specificity encoded in arrestin conformation?
- Monofunctional elements of multi-functional arrestin proteins
- Arrestins in cell death.
