Chromogranins: from Cell Biology to Physiology and Biomedicine

• Corporate Author: SpringerLink (Online service)
• Other Authors: Angelone, Tommaso (Editor), Cerra, Maria Carmela (Editor), Tota, Bruno (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Series: UNIPA Springer Series,
• Subjects: Medicine.; Human physiology.; Molecular biology.; Animal physiology.; Biomedicine.; Human Physiology.; Animal Physiology.; Molecular Medicine.

The volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine. The different chapters highlight novel activities of these proteins, including their role in granule biogenesis, h...

Table of Contents:

• Chromaffin cells and Granins: History and Perspectives
• The extended granin family: structure, function, and biomedical implications
• CgA and CgB in granule secretion
• Proteolytic processing of CgA and CgB/Antimicrobial properties of Chromogranins
• Chromogranins and inositol 1,4,5-trisphosphate-dependent Ca2+-signaling
• CgA in angiogenesis and tumor biology
• Full lenght CgA: a multifaceted protein in cardiovascular health and disease
• Physio-pharmacological aspects of three Chromogranin A-derived peptides: Vasostatin, Catestatin, and Serpinin
• Comparative aspects of CgA-derived peptides in cardiac homeostasis
• Molecular and cellular mechanisms of action of CgA-derived peptides in cardiomyocytes and endothelial cells
• CgA-derived peptides in pre- and post-conditioning cardioprotection
• Catestatin in physiopathology
• Serpinin: from biosynthesis to cell biology and physiopathology
• Pancreastatin and metabolism
• Chromogranins and the quantum release of catecholamines.