Centromeres and Kinetochores Discovering the Molecular Mechanisms Underlying Chromosome Inheritance /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Black, Ben E. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Σειρά: Progress in Molecular and Subcellular Biology, 56
• Θέματα: Life sciences.; Human genetics.; Cell cycle.; Cell physiology.; Life Sciences.; Cell Cycle Analysis.; Cell Physiology.; Human Genetics.

This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms contro...

Πίνακας περιεχομένων:

• Preface
• Use of Mass Spectrometry to Study the Centromere and Kinetochore
• Critical Foundation of the Kinetochore: the Constitutive Centromere Associated Network (CCAN)
• The Power of Xenopus Egg Extract for Reconstitution of Centromere and Kinetochore Function
• Centrochromatin of Fungi
• Evolutionary Lessons from Species with Unique Kinetochores.-Quantitative Microscopy Reveals Centromeric Chromatin Stability, Size, and Cell Cycle Mechanisms to Maintain Centromere Homeostasis
• Orchestrating the Specific Assembly of Centromeric Nucleosomes
• Artificial Chromosomes and Strategies to Initiate Epigenetic Centromere Establishment
• Post-translational Modifications of Centromeric Chromatin
• Centromere Silencing Mechanisms
• Centromere Transcription: Means and Motive
• The Promises and Challenges of Genomic Studies of Human Centromeres
• DNA Sequences in Centromere Formation and Function
• The Unique DNA Sequences Underlying Equine Centromeres
• Centromere Dynamics in Male and Female Germ Cells
• Cell Biology of Cheating—Transmission of Centromeres and Other Selfish Elements Through Asymmetric Meiosis
• Biophysics of Microtubule End Coupling at the Kinetochore
• Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing
• A Kinase-Phosphatase Network That Regulates Kinetochore-Microtubule Attachments and the SAC
• Centromeric Cohesion: Molecular Glue and Much More
• Centromere Structure and Function
• The Role of Centromere Defects in Cancer.