Phosphodiesterases: CNS Functions and Diseases
PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis. This family of enz...
| Συγγραφή απο Οργανισμό/Αρχή: | |
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| Άλλοι συγγραφείς: | , , |
| Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Cham :
Springer International Publishing : Imprint: Springer,
2017.
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| Σειρά: | Advances in Neurobiology,
17 |
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Part I. PDEs and Signaling, Circuitry, and Implications of CNS Functions and Disorders
- 1. Phosphodiesterase Diversity and Signal Processing within cAMP Signaling Networks
- 2. Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry
- 3. Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases
- 4. The PDE4 cAMP-specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-enhancing Action
- 5. Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-related Metabolic Diseases
- Part II. PDEs in Cognition of Aging and Alzheimer’s Disease
- 6. From age-related Cognitive Decline to Alzheimer’s Disease: A Translational Overview of the Potential role for Phosphodiesterases
- 7. The Past, Present, and Future of Phosphodiesterase-4 Modulation for age-induced Memory Loss
- 8. A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood
- 9. Role of PDE9 in Cognition
- Part III. PDEs in Parkinson’s and Huntington’s Diseases
- 10. Regulation of Striatal Neuron Activity by Cyclic Nucleotide Signaling and Phosphodiesterase Inhibition: Implications for the Treatment of Parkinson’s Disease
- 11. Role of Phosphodiesterases in Huntington's Disease
- Part IV. PDEs and Psychiatric Disorders
- 12. The role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders
- 13. Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction
- 14. PDE Inhibitors for the Treatment of Schizophrenia
- Part V. PDEs and Others
- 15. Targeting Phosphodiesterases in Pharmacotherapy for Substance Dependence
- 16. Genetic Understanding of Stroke Treatment: Potential role for Phosphodiesterase Inhibitors
- 17. A unique sub-pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS.
