Multiscale Mechanobiology of Bone Remodeling and Adaptation

• Corporate Author: SpringerLink (Online service)
• Other Authors: Pivonka, Peter (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: CISM International Centre for Mechanical Sciences, Courses and Lectures, 578
• Subjects: Mechanics.; Mechanics, Applied.; Biomaterials.; Orthopedics.; Solid Mechanics.
• Physical Description: XII, 287 p. 98 illus. online resource.
• ISBN: 9783319588452
• ISSN: 0254-1971 ;
• DOI: 10.1007/978-3-319-58845-2

The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.