Genome Editing in Neurosciences

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Jaenisch, Rudolf (Επιμελητής έκδοσης), Zhang, Feng (Επιμελητής έκδοσης), Gage, Fred (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Σειρά: Research and Perspectives in Neurosciences,
• Θέματα: Medicine.; Human genetics.; Neurosciences.; Biomedical engineering.; Biomedicine.; Human Genetics.; Biomedical Engineering/Biotechnology.

This book is open access under a CC BY 4.0 license. Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technolog...

Πίνακας περιεχομένων:

• Introduction
• In vitro modeling of complex neurological diseases
• Aquatic model organisms in neurosciences : the genome editing revolution
• Genome-wide genetic screening in the mammalian CNS
• CRISPR/Cas9-mediated Knockin and Knockout in Zebrafish
• Dissecting the role of synaptic proteins with CRISPR
• Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer
• Neuroscience research using non-human primate models and genome editing
• Multiscale genome engineering: Genome-wide screens and targeted approaches
• Using Genome Engineering to Understand Huntington’s Disease
• Therapeutic gene editing in muscles and muscle stem cells.