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02865nam a22005175i 4500 |
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978-3-319-60333-9 |
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DE-He213 |
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20170621171552.0 |
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cr nn 008mamaa |
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170621s2017 gw | s |||| 0|eng d |
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|a 9783319603339
|9 978-3-319-60333-9
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|a 10.1007/978-3-319-60333-9
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|a Correia Carreira, Sara.
|e author.
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|a Rapid Cell Magnetisation Using Cationised Magnetoferritin
|h [electronic resource] /
|c by Sara Correia Carreira.
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2017.
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|a XVII, 166 p. 90 illus., 16 illus. in color.
|b online resource.
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|a text
|b txt
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|a computer
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|a online resource
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|a text file
|b PDF
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|a Springer Theses, Recognizing Outstanding Ph.D. Research,
|x 2190-5053
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|a Introduction -- Materials and Methods -- Characterising Magnetoferritin and Cationised Magnetoferritin -- Stem Cell Labelling with Cationised Magnetoferritin -- Toxicological Profiling of Cationised Magnetoferritin -- Escherichia coli labelling with Cationised Magnetoferritin -- Overall Conclusions and Future Opportunities.
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|a Bringing together nanoscience with stem cell and bacterial cell biology, this thesis is truly interdisciplinary in scope. It shows that the creation of superparamagnetic nanoparticles inside a protein coat, followed by chemical functionalisation of the protein surface, provides a novel methodology for cell magnetisation using incubation times as short as one minute. Crucially, stem cell proliferation and multi-lineage differentiation capacity is not impaired after labelling. Due to the unspecific labelling mechanism, this thesis also shows that the same magnetic protein nanoparticles can be used for rapid bacterial magnetisation. Thus, it is possible to magnetically capture and concentrate pathogens from clinical samples quickly and highly efficiently.
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|a Physics.
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|a Nanochemistry.
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|a Stem cells.
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|a Magnetism.
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|a Magnetic materials.
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|a Physics.
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|a Biological and Medical Physics, Biophysics.
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|a Stem Cells.
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|a Magnetism, Magnetic Materials.
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|a Nanochemistry.
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9783319603322
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|a Springer Theses, Recognizing Outstanding Ph.D. Research,
|x 2190-5053
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|u http://dx.doi.org/10.1007/978-3-319-60333-9
|z Full Text via HEAL-Link
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|a ZDB-2-PHA
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|a Physics and Astronomy (Springer-11651)
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