Oncoimmunology A Practical Guide for Cancer Immunotherapy /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Zitvogel, Laurence (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Kroemer, Guido (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Έκδοση: 1st ed. 2018.
• Θέματα: Oncology .; Immunology.; Cancer research.; Oncology.; Cancer Research.

In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthroug...

Πίνακας περιεχομένων:

• Fundamental bases: Immunology for the non immunologist: Cellular and molecular bases of cancer immunosurveillance
• Innate immunity/NK in cancer immunosurveillance
• Biology of regulatory T cells
• Adenosine, P2R receptors.-Plasmacytoid DC dysfunctions in cancer
• Chemotherapy and MDSC
• Biology of Myeloid Derived Suppressor Cells
• T cell fitness/polarization for antitumor immune responses
• Tumor associated antigens and neoantigens
• Tumor associated antigens and neoantigens
• Immunization with peptides
• Immunogenic cell death and chemotherapy
• Breakthrough or advanced status of approaches: Cancer vaccines in HPV malignancies
• Innate sensing of tumors and TLR agonists
• DC-based cancer vaccines in melanoma
• DC-based vaccines in breast cancer
• T cell-based immunotherapies : CAR-T and TCR engineered T cells.-IDO and TDO-based inhibition in cancer. - FDA-EMA approval of I-O: Tumor-specific antibodies
• Anti-CTLA4 Abs
• Bispecific anti-CD3xCD19 antibodies
• Combination of ICB in MM
• Oncolytic viruses
• Bacillus Calmette-Guérin and mycobacterial cell wall nucleic acid complexes in the treatment of non-muscle-invasive bladder cancer
• The immunoscore
• PDL-1 and other immunological diagnosis tools
• Developping fields: The development of anti-41BB, Lag3, Anti-OX40, anti-ICOS, anti-GITR Ab
• mRNA-based vaccination
• Links between tumor genetics and immunotherapy
• Local immunotherapies of cancer
• Preventive DC-based cancer vaccines
• Gut microbiota/oncomicrobiotics in cancer therapeutics
• Strategies to reduce intratumoral Treg
• Cold versus hot tumors
• Immunopathology : an emerging field
• Changes in Clinical Practice: Side effects of I-O
• The clinical armamentarium in melanoma
• The clinical armamentarium in kidney cancers
• The clinical armamentarium in lung cancers
• The clinical armamentarium in prostate cancers
• Challenges of O-I for breast, ovarian, and non MSI colon cancers
• Challenges in colon cancers
• Current status of O-I in hematologic malignancies
• Glioma and I-O
• Assessing affinity and avidity of TCRs
• Immunomonitoring studies.