A Network-Based Approach to Cell Metabolism From Structure to Flux Balances /

This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures. The results reported here have a potential application in areas like metabolic engineering and disease treatment...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριος συγγραφέας: Güell, Oriol (Συγγραφέας)
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2017.
Σειρά:Springer Theses, Recognizing Outstanding Ph.D. Research,
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
Πίνακας περιεχομένων:
  • Cellular Metabolism at the Systems Level
  • Methods and Data
  • Structural Knockout Cascades in Metabolic Networks
  • Effects of Reaction Knockouts on Steady States of Metabolism
  • Detection of Evolution and Adaptation Fingerprints in Metabolic Networks
  • Assessing FBA Optimal States in the Feasible Flux Phenotypic Space
  • Conclusions.