A Network-Based Approach to Cell Metabolism From Structure to Flux Balances /

• Main Author: Güell, Oriol (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Chemistry.; Biochemical engineering.; Physical chemistry.; Systems biology.; Biochemical Engineering.; Systems Biology.; Physical Chemistry.

This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures. The results reported here have a potential application in areas like metabolic engineering and disease treatment...

Table of Contents:

• Cellular Metabolism at the Systems Level
• Methods and Data
• Structural Knockout Cascades in Metabolic Networks
• Effects of Reaction Knockouts on Steady States of Metabolism
• Detection of Evolution and Adaptation Fingerprints in Metabolic Networks
• Assessing FBA Optimal States in the Feasible Flux Phenotypic Space
• Conclusions.