Acute Promyelocytic Leukemia A Clinical Guide /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Abla, Oussama (Editor, http://id.loc.gov/vocabulary/relators/edt), Lo Coco, Francesco (Editor, http://id.loc.gov/vocabulary/relators/edt), Sanz, Miguel A. (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Subjects: Hematology.; Oncology .; Oncology.

This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences...

Table of Contents:

• History of APL
• Molecular Targets of Treatment in APL
• The Leukemic Stem Cell
• The Molecular Genetics of APL
• APL Coagulopathy
• Early Death in APL
• Prognostic Factors in APL
• First-line therapy for APL: Chemotherapy-based approach
• First-line Therapy: ATRA-ATO/Reduced Chemotherapy Approach
• Cure of APL without Chemotherapy
• Minimal Residual Disease in APL
• Treatment of refractory and relapsed APL
• Hematopoietic Stem Cell Transplantation in APL
• APL in Children
• Management of APL in the Elderly
• Special Situations in APL
• APL in Developing Countries: A Chemotherapy-Based Approach
• APL in Developing Countries: ATO based Approach
• Therapy-Related APL
• Rare Acute Leukemia Variants involving Retinoic Acid Receptor Genes
• Management of Treatment-Related Complications in APL.