Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control

• Corporate Author: SpringerLink (Online service)
• Other Authors: Gagneux, Sebastien (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Series: Advances in Experimental Medicine and Biology, 1019
• Subjects: Life sciences.; Drug resistance.; Bacteriology.; Life Sciences.; Drug Resistance.

Until about 10 years ago, the general view in the field was that Mycobacterium tuberculosis, the causative agent of human tuberculosis was a “clone” with insufficient natural sequence variation between clinical strains to be considered biologically and epidemiologically “relevant”. This view has now...

Table of Contents:

• Chapter 1. The Nature and Evolution of Genomic Diversity in the Mycobacterium tuberculosis Complex
• Chapter 2. The Biology and Epidemiology of Mycobacterium canettii
• Chapter 3. The Evolution of Strain Typing in the Mycobacterium tuberculosis Complex
• Chapter 4. Genomic Epidemiology of Tuberculosis
• Chapter 5. Biological and Epidemiological Consequences of MTBC Diversity
• Chapter 6. The Biology and Epidemiology of Mycobacterium africanum
• Chapter 7. Mycobacterium tuberculosis Complex Members Adapted to Wild and Domestic Animals
• Chapter 8. Evolution and Strain Variation in BCG
• Chapter 9. Antigenic Variation and Immune Escape in the MTBC
• Chapter 10. PE and PPE Genes: A Tale of Conservation and Diversity
• Chapter 11. Epidemiology of Drug-resistant Tuberculosis
• Chapter 12. Evolution of Phenotypic and Molecular Drug Susceptibility Testing
• Chapter 13.  DNA Replication Fidelity in the Mycobacterium tuberculosis Complex
• Chapter 14. Strain Diversity and the Evolution of Antibiotic Resistance
• Chapter 15. Mathematical Models for the Epidemiology and Evolution of Mycobacterium tuberculosis.