D-type Cyclins and Cancer

• Corporate Author: SpringerLink (Online service)
• Other Authors: Hinds, Philip W. (Editor, http://id.loc.gov/vocabulary/relators/edt), Brown, Nelson E. (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Humana, 2018.
• Edition: 1st ed. 2018.
• Series: Current Cancer Research,
• Subjects: Cancer research.; Cell cycle.; Molecular biology.; Cancer Research.; Cell Cycle Analysis.; Molecular Medicine.

This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new...

Table of Contents:

• The D-type Cyclins: A Historical Perspective
• Mammalian Development and Cancer - A Brief History of Mice Lacking D-type Cyclins or Cdk4/6
• D-type Cyclins and Gene Transcription
• Splice Variants and Phosphorylated Isoforms of Cyclin D1 in Tumorigenesis
• Cyclin D1, Metabolism, and the Autophagy-Senescence Balance
• Shifting a Paradigm: Cyclin D Activates pRb by Mono-Phosphorylation.