Coupling and Decoupling of Diverse Molecular Units in Glycosciences

This unique book covers the latest developments in coupling and decoupling of biomolecules containing functionalized carbohydrate components, being one of the first collections in this important area of applied medicinal chemistry. Connecting molecules, often referred as bio-conjugation, has become...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Witczak, Zbigniew J. (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Bielski, Roman (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2018.
Έκδοση:1st ed. 2018.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
Πίνακας περιεχομένων:
  • Synthesis of N-linked glycopeptides using convergent enzymatic glycosylation combined with SPPS.- Synthetic Antitumor Vaccines through Coupling of Mucin Glycopeptide Antigens to Proteins.- Recent Advances in the Stereochemical Outcome of Multi Component Reactions Involving Convertible Isocyanides.- Glycoconjugate-based inhibitors of Mycobacterium tuberculosis GlgE.- Selective Transformations of the Anomeric Centre in Water Using DMC and Derivatives
  • [3,3]-Sigmatropic Rearrangement as a Powerful Synthetic Tool on Skeletal Modification of Unsaturated Sugars
  •  Recognition of thiols in coupling reactions to organic and carbohydrate acceptors.- Chemical approaches toward neurodegenerative disease prevention: the role of coupling sugars to phenolic biomolecular entities
  •  Probing for Trypanosoma cruzi cell surface glycobiomarkers for the diagnosis and follow-up of chemotherapy of Chagas disease
  •  Syntheses and Functions Glycosaminoglycan Mimicking Polymers.- Methods for the high resolution analysis of glycoconjugates.- Masking Strategies for the Bioorthogonal Release of Anticancer Glycosides.- Example of Sacrificial Unit Using Two Different Click Reactions in Coupling and Decoupling (CAD) Chemistry.- Increased efficacy of NKT cell adjuvanted peptide vaccines through chemical conjugation.