Sigma Proteins: Evolution of the Concept of Sigma Receptors

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Kim, Felix J. (Επιμελητής έκδοσης), Pasternak, Gavril W. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Σειρά: Handbook of Experimental Pharmacology, 244
• Θέματα: Medicine.; Cancer research.; Human genetics.; Human physiology.; Neurosciences.; Pharmaceutical technology.; Biomedicine.; Human Physiology.; Human Genetics.; Cancer Research.; Pharmaceutical Sciences/Technology.

Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is highly c...