Sigma Proteins: Evolution of the Concept of Sigma Receptors
Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is highly c...
Συγγραφή απο Οργανισμό/Αρχή: | |
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Άλλοι συγγραφείς: | , |
Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
Γλώσσα: | English |
Έκδοση: |
Cham :
Springer International Publishing : Imprint: Springer,
2017.
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Σειρά: | Handbook of Experimental Pharmacology,
244 |
Θέματα: | |
Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Preface
- Historical perspective and background - including Sigma protein subtypes and ligand selectivity
- Sigma imaging agents
- Medicinal chemistry
- 3-dimensional homology models of Sigma1
- Neuronal plasticity and ion channels
- Opioid receptors and other GPCR
- Cancer
- Neurodegenerative diseases
- Pain
- Cognition, learning, neurological disorders
- Drug abuse and addiction
- Alcohol Abuse
- Stroke and neuroprotection.