Sigma Proteins: Evolution of the Concept of Sigma Receptors

• Corporate Author: SpringerLink (Online service)
• Other Authors: Kim, Felix J. (Editor), Pasternak, Gavril W. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Series: Handbook of Experimental Pharmacology, 244
• Subjects: Medicine.; Cancer research.; Human genetics.; Human physiology.; Neurosciences.; Pharmaceutical technology.; Biomedicine.; Human Physiology.; Human Genetics.; Cancer Research.; Pharmaceutical Sciences/Technology.

Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is highly c...

Table of Contents:

• Preface
• Historical perspective and background - including Sigma protein subtypes and ligand selectivity
• Sigma imaging agents
• Medicinal chemistry
• 3-dimensional homology models of Sigma1
• Neuronal plasticity and ion channels
• Opioid receptors and other GPCR
• Cancer
• Neurodegenerative diseases
• Pain
• Cognition, learning, neurological disorders
• Drug abuse and addiction
• Alcohol Abuse
• Stroke and neuroprotection.