Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Yarden, Yosef (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Elkabets, Moshe (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Έκδοση: 1st ed. 2018.
• Σειρά: Resistance to Targeted Anti-Cancer Therapeutics, 15
• Θέματα: Cancer research.; Cancer Research.

This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essenti...

Πίνακας περιεχομένων:

• Resistance of colorectal tumors to anti-EGFR antibodies
• Resistance of lung cancer to kinase inhibitors specific to EGFR or ALK
• Mechanisms of action and resistance of trastuzumab in breast cancer
• Mechanisms of resistance to molecular therapies targeting the HGF/MET axis
• RAF, MEK and ERK inhibitors as anti-cancer drugs: intrinsic and acquired resistance as a major therapeutic challenge
• Mechanisms of resistance to PI3K and AKT inhibitors
• Sensitivity and resistance to BH3 mimetics in cancer therapy
• Resistance mechanisms to cyclin-dependent kinase inhibitors
• Resistance to inhibitors of angiogenesis.