Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

• Corporate Author: SpringerLink (Online service)
• Other Authors: Yoshimura, Akihiko (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Series: Current Topics in Microbiology and Immunology, 410
• Subjects: Medicine.; Cancer research.; Immunology.; Cell biology.; Biomedicine.; Cancer Research.; Cell Biology.

This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules...

Table of Contents:

• Regulatory T cells: molecular and cellular basis for immunoregulation
• Overview of LAG-3- expressing, IL-10-producing regulatory T cells
• Regulatory Dendritic Cells
• Role of PD-1 in immunity and diseases
• CTLA-4, an essential immune-checkpoint for T cell activation
• Tim-3, Lag-3, and TIGIT
• SOCS1: regulator of T cells in autoimmunity and cancer
• Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity
• Immune regulation by ubiquitin tagging as checkpoint code
• MicroRNA in Immune Regulation.