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03445nam a2200493 4500 |
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978-3-319-74164-2 |
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DE-He213 |
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20191220130536.0 |
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cr nn 008mamaa |
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180418s2018 gw | s |||| 0|eng d |
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|a 9783319741642
|9 978-3-319-74164-2
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|a 10.1007/978-3-319-74164-2
|2 doi
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|a RM1-950
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|a 615
|2 23
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|a Targeting Trafficking in Drug Development
|h [electronic resource] /
|c edited by Alfredo Ulloa-Aguirre, Ya-Xiong Tao.
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|a 1st ed. 2018.
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2018.
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| 300 |
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|a VIII, 425 p. 57 illus.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a text file
|b PDF
|2 rda
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| 490 |
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|a Handbook of Experimental Pharmacology,
|x 0171-2004 ;
|v 245
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|a 1. Intracellular trafficking of gonadotropin receptors in health and disease -- 2. Investigating internalization and intracellular trafficking of GPCRs -- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors -- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases -- 5. Pharmacoperones for misfolded gonadotropin receptors -- 6. Pharmacological chaperones: Beyond conformational disorders -- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer -- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches -- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking -- 10. SLC6 transporter folding diseases and pharmacochaperoning -- 11. The molecular physiopathogenesis of islet amyloidosis -- 12. Folding defects leading to primary hyperoxaluria -- 13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria. .
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| 520 |
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|a Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.
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| 650 |
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|a Pharmacology.
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| 650 |
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|a Cell biology.
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| 650 |
1 |
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|a Pharmacology/Toxicology.
|0 http://scigraph.springernature.com/things/product-market-codes/B21007
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| 650 |
2 |
4 |
|a Cell Biology.
|0 http://scigraph.springernature.com/things/product-market-codes/L16008
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| 700 |
1 |
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|a Ulloa-Aguirre, Alfredo.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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| 700 |
1 |
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|a Tao, Ya-Xiong.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 776 |
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8 |
|i Printed edition:
|z 9783319741635
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| 776 |
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8 |
|i Printed edition:
|z 9783319741659
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| 776 |
0 |
8 |
|i Printed edition:
|z 9783030089276
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| 830 |
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|a Handbook of Experimental Pharmacology,
|x 0171-2004 ;
|v 245
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| 856 |
4 |
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|u https://doi.org/10.1007/978-3-319-74164-2
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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