Targeting Trafficking in Drug Development

• Corporate Author: SpringerLink (Online service)
• Other Authors: Ulloa-Aguirre, Alfredo (Editor, http://id.loc.gov/vocabulary/relators/edt), Tao, Ya-Xiong (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Handbook of Experimental Pharmacology, 245
• Subjects: Pharmacology.; Cell biology.; Pharmacology/Toxicology.; Cell Biology.

Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are exp...

Table of Contents:

• 1. Intracellular trafficking of gonadotropin receptors in health and disease
• 2. Investigating internalization and intracellular trafficking of GPCRs
• 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors
• 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases
• 5. Pharmacoperones for misfolded gonadotropin receptors
• 6. Pharmacological chaperones: Beyond conformational disorders
• 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer
• 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches
• 9. Conserved oligomeric Golgi and neuronal vesicular trafficking
• 10. SLC6 transporter folding diseases and pharmacochaperoning
• 11. The molecular physiopathogenesis of islet amyloidosis
• 12. Folding defects leading to primary hyperoxaluria
• 13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria. .