Drug Resistance in Leishmania Parasites Consequences, Molecular Mechanisms and Possible Treatments /
Drug resistance is a fundamental factor in treatment failure in diseases like leishmaniasis, although additional factors also play a role in this phenomenon. This volume is the second edition of a well-received book that provides a comprehensive update on the pathology of the disease, as well as on...
| Συγγραφή απο Οργανισμό/Αρχή: | |
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| Άλλοι συγγραφείς: | , |
| Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Cham :
Springer International Publishing : Imprint: Springer,
2018.
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| Έκδοση: | 2nd ed. 2018. |
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Prologue
- Introduction
- Part I Determinant features in Leishmaniasis
- Molecular evolution and phylogeny of Leishmania
- The role of reservoirs: canine Leishmaniasis
- Epidemiology of Leishmaniasis in the time of drug resistance
- The role of the immune system in resistance to infection
- Part II Challenges in the diagnosis, treatment and control of Leishmaniasis in the times of drug resistance
- Co-infection with HIV
- Visceral Leishmaniasis
- Tegumentary Leishmaniasis
- Antimony accounted sequel post Kala-Azar dermal Leishmaniasis
- Part III Molecular featrues of drug resistant Leishmania
- Genetic Expression and drug resistance, the role of proteomics
- The role of AMC transporters in drug-resistant Leishmania
- Functional analysis of Leishmania membrane (non AMC) transporters involved in drug resistance
- Part IV Pharmacology and chemotherapy of Leishmaniasis
- Classical vs. novel treatment regimens
- Bioinformatics in Leishmania drug design
- Leishmanis mitochondria, a druggable organelle
- P-glycoprotein-like transporters in Leishmania: a search for reversal agents
- Part V Strategies to circumvent drug resistance in Leishmania
- The relevance of susceptibility tests, breakpoints and markers
- The concept of fitness in Leishmania.
