Bioinformatics Techniques for Drug Discovery Applications for Complex Diseases /

• Main Authors: Kaushik, Aman Chandra (Author, http://id.loc.gov/vocabulary/relators/aut), Kumar, Ajay (http://id.loc.gov/vocabulary/relators/aut), Bharadwaj, Shiv (http://id.loc.gov/vocabulary/relators/aut), Chaudhary, Ravi (http://id.loc.gov/vocabulary/relators/aut), Sahi, Shakti (http://id.loc.gov/vocabulary/relators/aut)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: SpringerBriefs in Computer Science,
• Subjects: Bioinformatics.; Systems biology.; Pharmacology.; Computational Biology/Bioinformatics.; Systems Biology.; Pharmacology/Toxicology.
• Physical Description: XI, 57 p. 8 illus., 7 illus. in color. online resource.
• ISBN: 9783319757322
• ISSN: 2191-5768
• DOI: 10.1007/978-3-319-75732-2

The application of bioinformatics approaches in drug design involves an interdisciplinary array of sophisticated techniques and software tools to elucidate hidden or complex biological data. This work reviews the latest bioinformatics approaches used for drug discovery. The text covers ligand-based and structure-based approaches for computer-aided drug design, 3D pharmacophore modeling, molecular dynamics simulation, the thermodynamics of ligand−receptor and ligand−enzyme association, thermodynamic characterization and optimization, and techniques for computational genomics and proteomics.