Investigation of Nanoscopic Dynamics and Potentials by Interferometric Scattering Microscopy

• Main Author: Ortega Arroyo, Jaime (Author, http://id.loc.gov/vocabulary/relators/aut)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Physical chemistry.; Organic chemistry.; Cell biology.; Atoms.; Physics.; Physical Chemistry.; Organic Chemistry.; Cell Biology.; Atomic, Molecular, Optical and Plasma Physics.

This thesis offers a unique guide to the development and application of ultrasensitive optical microscopy based on light scattering. Divided into eight chapters, it covers an impressive range of scientific fields, from basic optical physics to molecular biology and synthetic organic chemistry. Espec...

Table of Contents:

• Introduction
• Non-fluorescent single-molecule approaches to optical microscopy
• Experimental Methods
• Anomalous diffusion due to interleaflet coupling and molecular pinning
• Structural dynamics of myiosin 5a
• All optical label-free detection, imaging and tracking of single proteins
• Single-molecule chemical dynamics: direct observation of physical autocatalysis
• Outlook.