Acute Neuronal Injury The Role of Excitotoxic Programmed Cell Death Mechanisms /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Fujikawa, Denson G. (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 2nd ed. 2018.
• Subjects: Neurosciences.; Neurology .; Pathology.; Cell biology.; Neurobiology.; Psychiatry.; Neurology.; Cell Biology.

An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in...

Table of Contents:

• Introduction
• Excitotoxic programmed cell death involves caspase-independent mechanisms
• To survive or to die: how neurons deal with it
• Oxidative damage mechanisms in traumatic brain injury and antioxidant neuroprotective approaches
• Mitochondrial damage in traumatic CNS injury
• Neuroprotective agents target molecular mechanisms of programmed cell death after traumatic brain injury
• Involvement of apoptosis-inducing factor (AIF) in neuronal death following cerebral ischemia
• Apoptosis-inducing factor translocation to nuclei after transient global ischemia
• Necroptosis in cerebral ischemia
• Histological and elemental changes in ischemic stroke
• Hypoglycemic brain damage
• Activation of caspase-independent programmed pathways in seizure-induced neuronal necrosis
• Conclusion.