Innovations for Next-Generation Antibody-Drug Conjugates

• Corporate Author: SpringerLink (Online service)
• Other Authors: Damelin, Marc (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Humana, 2018.
• Edition: 1st ed. 2018.
• Series: Cancer Drug Discovery and Development,
• Subjects: Cancer research.; Molecular biology.; Cancer Research.; Molecular Medicine.

Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the i...

Table of Contents:

• Chapter 1 Introduction: Motivations for Next-Generation ADCs
• Chapter 2 Combining ADCs with Immuno-oncology Agents
• Chapter 3 Improving the Safety Profile of ADCs
• Chapter 4 Utility of PK-PD Modeling and Simulation to Improve Decision Making for Antibody-Drug Conjugate Development
• Chapter 5 Regulatory Considerations and Companion Diagnostics
• Chapter 6 ADC Process Development and Manufacturing
• Chapter 7 HER2-Targeted ADCs: At the forefront of ADC technology development
• Chapter 8 Next generation payloads for ADCs
• Chapter 9 Delivering more payload: High DAR ADCs
• Chapter 10 Site-Specific Antibody Drug Conjugates
• Chapter 11 Bispecific and Biparatopic Antibody-Drug Conjugates
• Chapter 12 drug conjugates to the tumor microenvironment: Probody Drug Conjugates
• Chapter 13 Antibody-Drug Conjugates: Targeting the Tumor Microenvironment
• Chapter 14 Next Horizons: ADCs Beyond Oncology.