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04079nam a2200589 4500 |
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978-3-319-89354-9 |
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DE-He213 |
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20191021192807.0 |
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|a 9783319893549
|9 978-3-319-89354-9
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|a 10.1007/978-3-319-89354-9
|2 doi
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|a 570
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|a Álvarez-Buylla Roces, María Elena.
|e author.
|4 aut
|4 http://id.loc.gov/vocabulary/relators/aut
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|a Modeling Methods for Medical Systems Biology
|h [electronic resource] :
|b Regulatory Dynamics Underlying the Emergence of Disease Processes /
|c by María Elena Álvarez-Buylla Roces, Juan Carlos Martínez-García, José Dávila-Velderrain, Elisa Domínguez-Hüttinger, Mariana Esther Martínez-Sánchez.
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| 250 |
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|a 1st ed. 2018.
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| 264 |
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1 |
|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2018.
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| 300 |
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|a XXI, 258 p. 60 illus. in color.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 347 |
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|a text file
|b PDF
|2 rda
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| 490 |
1 |
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 1069
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| 505 |
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|a Introduction -- Medical systems biology -- Modeling procedures -- Case of study -- Conclusions and Perspectives -- Bibliography.
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| 520 |
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|a This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.
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| 650 |
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|a Systems biology.
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| 650 |
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|a Microbial genetics.
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| 650 |
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|a Microbial genomics.
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| 650 |
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|a Mathematical models.
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| 650 |
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|a Bioinformatics.
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| 650 |
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|a Systems Biology.
|0 http://scigraph.springernature.com/things/product-market-codes/L15010
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| 650 |
2 |
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|a Microbial Genetics and Genomics.
|0 http://scigraph.springernature.com/things/product-market-codes/L32010
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| 650 |
2 |
4 |
|a Mathematical Modeling and Industrial Mathematics.
|0 http://scigraph.springernature.com/things/product-market-codes/M14068
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| 650 |
2 |
4 |
|a Computational Biology/Bioinformatics.
|0 http://scigraph.springernature.com/things/product-market-codes/I23050
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| 700 |
1 |
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|a Martínez-García, Juan Carlos.
|e author.
|4 aut
|4 http://id.loc.gov/vocabulary/relators/aut
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| 700 |
1 |
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|a Dávila-Velderrain, José.
|e author.
|4 aut
|4 http://id.loc.gov/vocabulary/relators/aut
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| 700 |
1 |
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|a Domínguez-Hüttinger, Elisa.
|e author.
|4 aut
|4 http://id.loc.gov/vocabulary/relators/aut
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| 700 |
1 |
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|a Martínez-Sánchez, Mariana Esther.
|e author.
|4 aut
|4 http://id.loc.gov/vocabulary/relators/aut
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 776 |
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8 |
|i Printed edition:
|z 9783319893532
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| 776 |
0 |
8 |
|i Printed edition:
|z 9783319893556
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| 776 |
0 |
8 |
|i Printed edition:
|z 9783030077488
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| 830 |
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 1069
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| 856 |
4 |
0 |
|u https://doi.org/10.1007/978-3-319-89354-9
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
|
