Molecular Mechanisms of Notch Signaling

• Corporate Author: SpringerLink (Online service)
• Other Authors: Borggrefe, Tilman (Editor, http://id.loc.gov/vocabulary/relators/edt), Giaimo, Benedetto Daniele (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Advances in Experimental Medicine and Biology, 1066
• Subjects: Proteins .; Receptors.; Protein-Ligand Interactions.; Protein Structure.

This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular...