RNA Metabolism in Neurodegenerative Diseases

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Sattler, Rita (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Donnelly, Christopher J. (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Έκδοση: 1st ed. 2018.
• Σειρά: Advances in Neurobiology, 20
• Θέματα: Neurosciences.

It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes...

Πίνακας περιεχομένων:

• RNA Metabolism in Neurodegenerative Diseases
• Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes
• RNA Editing Deficiency in Neurodegeneration
• RNA Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases
• RNA Degradation in Neurodegenerative Disease
• RNP Assembly Defects in Spinal Muscular Atrophy
• Stress Granules and ALS: A Case of Causation or Correlation?
• Deregulation of RNA Metabolism in Microsatellite Expansion Diseases
• Mechanisms Associated with TDP-43 Neurotoxicity in ALS/FTLD
• Senataxin, a Novel Helicase at the Interface of RNA Transcriptome Regulation and Neurobiology: From Normal Function to Pathological Roles in Motor Neuron Disease and Cerebellar Degeneration
• Lost in Translation - Evidence for Protein Synthesis Deficits in ALS/FTD and Related Neurodegenerative Diseases.