RNA Metabolism in Neurodegenerative Diseases

• Corporate Author: SpringerLink (Online service)
• Other Authors: Sattler, Rita (Editor, http://id.loc.gov/vocabulary/relators/edt), Donnelly, Christopher J. (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Advances in Neurobiology, 20
• Subjects: Neurosciences.

It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes...

Table of Contents:

• RNA Metabolism in Neurodegenerative Diseases
• Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes
• RNA Editing Deficiency in Neurodegeneration
• RNA Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases
• RNA Degradation in Neurodegenerative Disease
• RNP Assembly Defects in Spinal Muscular Atrophy
• Stress Granules and ALS: A Case of Causation or Correlation?
• Deregulation of RNA Metabolism in Microsatellite Expansion Diseases
• Mechanisms Associated with TDP-43 Neurotoxicity in ALS/FTLD
• Senataxin, a Novel Helicase at the Interface of RNA Transcriptome Regulation and Neurobiology: From Normal Function to Pathological Roles in Motor Neuron Disease and Cerebellar Degeneration
• Lost in Translation - Evidence for Protein Synthesis Deficits in ALS/FTD and Related Neurodegenerative Diseases.