Voltage-gated Sodium Channels: Structure, Function and Channelopathies

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Chahine, Mohamed (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Έκδοση: 1st ed. 2018.
• Σειρά: Handbook of Experimental Pharmacology, 246
• Θέματα: Pharmacology.; Human genetics.; Human physiology.; Proteins .; Pharmacology/Toxicology.; Human Genetics.; Human Physiology.; Protein Structure.

This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophy...

Πίνακας περιεχομένων:

• Preface
• Part I
• Evolution of voltage-gated sodium channels
• 1. Evolutionary History of Voltage-Gated Sodium Channels
• 2. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. - Part II. The structural basis of sodium channel function
• 3. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective
• 4. The Cardiac Sodium Channel and Its Protein Partners
• 5. : Posttranslational Modification of Sodium Channels
• 6. Sodium Channel Trafficking
• 7. pH Modulation of Voltage-Gated Sodium Channels
• 8. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C
• Part III. Drugs and toxins interactions with sodium channels
• 9. Toxins That Affect Voltage-Gated Sodium Channels
• 10. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels
• 11. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels
• 12. Structural Models of Ligand-Bound Sodium Channels
• 13. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7
• Part IV. Pathophysiology of sodium channels
• 14. Sodium Channelopathies of Skeletal Muscle
• 15. Cardiac Arrhythmias Related to Sodium Channel Dysfunction
• 16. Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain
• 17. Gating Pore Currents in Sodium Channels
• 18. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells
• 19. Voltage-Gated Sodium Channel b Subunits and Their Related Diseases. .