Inflammatory Mechanisms in Mediating Hearing Loss

• Corporate Author: SpringerLink (Online service)
• Other Authors: Ramkumar, Vickram (Editor, http://id.loc.gov/vocabulary/relators/edt), Rybak, Leonard P. (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Subjects: Neurosciences.; Otorhinolaryngology.

The primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this process translates into cochlear inflammation. Basic cellular mechanisms underlying the contribution of oxidant stress to hearing loss will be...

Table of Contents:

• Preface
• The Cochlea
• Oxidative Stress and Hearing Loss
• Corticotropin Releasing Factor Signaling in the Mammalian Cochlea: An Integrative Niche for Cochlear Homeostatic Balance Against Noise
• Cochlear vascular pathology and hearing loss
• Cochlear Inflammation Associated with Noise-Exposure
• Middle Ear Infection and Hearing Loss
• Inflammation potentiates cochlear uptake of ototoxins and drug-induced hearing loss
• The Contribution of Anti-Oxidant and Anti-Inflammatory Functions of Adenosine A1 Receptor In Mediating Otoprotection
• Anti-inflammatory therapies for sensorineural hearing loss
• Implementation and Outcomes of Clinical Trials in Immune-Mediated Hearing Loss and other Rare Diseases
• Index.