Alagille Syndrome Pathogenesis and Clinical Management /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Kamath, Binita M. (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Loomes, Kathleen M. (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Έκδοση: 1st ed. 2018.
• Θέματα: Gastroenterology .; Hepatology.; Cardiology.; Gastroenterology.

This text provides a concise yet comprehensive overview of Alagille syndrome. The book reviews the pathophysiology and genetics of the disorder, discusses recent molecular advances and its impact on diagnostics, and describes management challenges and strategies. The text also touches upon future tr...

Πίνακας περιεχομένων:

• The Alagille Syndrome: Overview and Introduction
• Bile Duct Development and the Notch Signaling Pathway
• Genetics of Alagille Syndrome
• Liver Disease in Alagille Syndrome
• Transplant Considerations in Alagille Syndrome
• Cardiac, Aortic, and Pulmonary Vascular Involvement in Alagille Syndrome
• Vascular Manifestations in Alagille Syndrome
• The Renal Sequelae of Alagille Syndrome as a Product of Altered Notch Signaling During Kidney Development
• Skeletal Involvement in Alagille Syndrome
• Immune Dysregulation in Alagille Syndrome: A Feature of the Evolving Phenotype
• Health-Related Quality of Life and Neurocognition in Alagille Syndrome
• Future Therapeutic Approaches for Alagille Syndrome.