Mathematical Modeling of Protein Complexes

• Main Authors: Koshlan, Tatiana (Author, http://id.loc.gov/vocabulary/relators/aut), Kulikov, Kirill (http://id.loc.gov/vocabulary/relators/aut)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Biological and Medical Physics, Biomedical Engineering,
• Subjects: Biophysics.; Biological physics.; Proteins .; Physics.; Biomathematics.; Biomedical engineering.; Biological and Medical Physics, Biophysics.; Protein Structure.; Numerical and Computational Physics, Simulation.; Mathematical and Computational Biology.; Biomedical Engineering and Bioengineering.
• Physical Description: XIV, 367 p. 65 illus., 48 illus. in color. online resource.
• ISBN: 9783319983042
• ISSN: 1618-7210
• DOI: 10.1007/978-3-319-98304-2

This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules. The models developed show remarkable sensitivity to the amino acid sequences of proteins, which facilitates experimental studies and allows one to reduce the associated costs by reducing the number of measurements required according to the developed criteria. These models make it possible to reach a conclusion about the interactions between different amino acid chains and to identify more stable sites on proteins. The models also take the phosphorylation of amino acid residues into account. At the end of the book, the authors present possible directions of application of their physical and mathematical models in clinical medicine.