Mathematical Modeling of Protein Complexes

• Main Authors: Koshlan, Tatiana (Author, http://id.loc.gov/vocabulary/relators/aut), Kulikov, Kirill (http://id.loc.gov/vocabulary/relators/aut)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Biological and Medical Physics, Biomedical Engineering,
• Subjects: Biophysics.; Biological physics.; Proteins .; Physics.; Biomathematics.; Biomedical engineering.; Biological and Medical Physics, Biophysics.; Protein Structure.; Numerical and Computational Physics, Simulation.; Mathematical and Computational Biology.; Biomedical Engineering and Bioengineering.

This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules. The models developed show remarkable sensitivity to the amino acid sequences of proteins, which facilitates experimental studies and allows one to reduce the associated costs by reducin...

Table of Contents:

• Introduction
• Physical methods for studying proteins
• Physical properties of amino acids and proteins
• Selection of a biological objects
• Mathematical simulation of complex formation of protein molecules allowing for their domain structure
• Mathematical modeling of histone dimers formation in vitro with solutions of different ionic strength in the presence of monovalent salts
• Mathematical modeling of the temperature effect on binding of monomeric proteins in aqueous solutions by example on histones H2A, H2B, H3 and H4
• Mathematical modeling of the temperature effect on binding of different sites of protein BCL-XL in aqueous solutions
• Mathematical modeling of the phosphorylation effect on the nature formation of biological complexes P53-MDM2 and P53-P300.