Estrogen Receptor and Breast Cancer Celebrating the 60th Anniversary of the Discovery of ER /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Zhang, Xiaoting (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Humana, 2019.
• Έκδοση: 1st ed. 2019.
• Σειρά: Cancer Drug Discovery and Development,
• Θέματα: Cancer research.; Molecular biology.; Cancer Research.; Molecular Medicine.

The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has b...

Πίνακας περιεχομένων:

• 1. Introduction: On the discovery of Estrogen Receptor
• 2. Physiological and Pathological Roles of Estrogen Receptor
• 3. Estrogen Receptor Cofactors
• 4. ER-Mediated Gene Transcription
• 5. ER Transcriptome
• 6. Estrogen Receptor Regulation of Non-Coding RNAs in Breast Cancer
• 7. First Targeted Therapy
• - History of Tamoxifen
• 8. Selective Estrogen Receptor Modulators (SERMs)
• 9. New Estrogen Receptor Drugs
• 10. Endocrine Therapy in Clinical Practice
• 11. Structural Insights into ER and Anti-Estrogen Therapies
• 12. Molecular Mechanisms of Endocrine Resistance
• 13. Estrogen Receptor Mutants in Breast Cancer
• 14. Estrogen Receptor Beta and Isoforms in Breast Cancer
• 15. Xenoestrogens, Phytoestrogens and Breast Cancer
• 16. Emerging Approaches to Overcome Endocrine Resistance.