Lessons on Caffeine, Cannabis & Co Plant-derived Drugs and their Interaction with Human Receptors /

• Main Authors: Böttger, Angelika (Author, http://id.loc.gov/vocabulary/relators/aut), Vothknecht, Ute (http://id.loc.gov/vocabulary/relators/aut), Bolle, Cordelia (http://id.loc.gov/vocabulary/relators/aut), Wolf, Alexander (http://id.loc.gov/vocabulary/relators/aut)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Learning Materials in Biosciences,
• Subjects: Pharmacology.; Plant biochemistry.; Science education.; Biotechnology.; Cancer research.; Molecular biology.; Pharmacology/Toxicology.; Plant Biochemistry.; Science Education.; Cancer Research.; Molecular Medicine.

This textbook provides a structured, easy to understand and thorough insight into the mode of function of plant secondary metabolites in plants and humans. It explains the biosynthesis and molecular action of nicotine, cannabis, caffeine and Co, describes the effects of these drugs on signal transdu...

Table of Contents:

• Introduction: Plant secondary metabolites and their general function in plants
• Historical and current perspective
• Medicinal use
• Recreational use
• General overview over biosynthesis pathways of plant secondary metabolites
• Drugs affecting GPCR: GPCRs in plants and animals
• Dopamine and 5-HT2A-serotonin receptors - Cocaine, mescaline, psilobin
• Opiate receptors - morphine, salvinorin A
• Cannabinoid receptors - THC
• Muscarinergic acetylcholin receptor - muscarin, atropine
• Adenosine receptor - caffeine
• Drugs affecting ion channels: Ligand and voltage activated channels
• Nicotinic acetylcholin receptor - Nicotine, Curare
• GABAA/C-receptor - Muscimol, thujone
• ionotropic Glycine receptor - Strychnine
• ionotropic Glutamate receptor - ibogtenic acid, kainic acid
• TRP channels - capsaicin, menthol, aconitine, resiniferatoxin
• Anti-cancer drugs acting on the cell cycle: Cell cycle in animals and plants
• Microtubuli - Colchicine, taxol, vinblastine, Podophyllotoxin (Lignan)
• Topoisomerase - camptothecin, etoposide
• G2/M phase arrest, apoptosis - curcubitacin, triptolide.