Molecular Analysis of B Lymphocyte Development and Activation

• Corporate Author: SpringerLink (Online service)
• Other Authors: Singh, Harinder (Editor), Grosschedl, Rudolf (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2005.
• Series: Current Topics in Microbiology and Immunology, 290
• Subjects: Medicine.; Immunology.; Biomedicine.

The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell...

Table of Contents:

• Gene Regulatory Networks Orchestrating B Cell Fate Specification, Commitment, and Differentiation
• Helix-Loop-Helix Proteins in Lymphocyte Lineage Determination
• Ikaros-Family Proteins: In Search of Molecular Functions During Lymphocyte Development
• Biochemistry of V(D)J Recombination
• The pre-B cell Receptor in B Cell Development: Recent Advances, Persistent Questions and Conserved Mechanisms
• Transcriptional Control of B Cell Activation
• Expression of MHC II Genes
• Class Switch Recombination: An Emerging Mechanism
• Blimp-1; Immunoglobulin Secretion and the Switch to Plasma Cells
• Wnt Signaling in Lymphopoiesis.