Axonal Branching and Recovery of Coordinated Muscle Activity after Transection of the Facial Nerve in Adult Rats

• Main Authors: Angelov, Doychin N. (Author), Neiss, Wolfram F. (Author), Guntinas-Lichius, Orlando (Author), Streppel, Michael (Author), Wewetzer, Konstantin (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2005.
• Series: Advances in Anatomy Embryology and Cell Biology, 180
• Subjects: Medicine.; Neurosciences.; Biomedicine.

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Table of Contents:

• Outline of the General Neurobiological Problem
• The Perikarya Which Support Axonal Regrowth are Hyperexcitable
• Axonal Regrowth is Compromised by Ephaptic Cross-Talk Between the Branches
• Biological Significance of Axonal Branching
• Role of Cytoskeleton Reorganization During Axonal Branching
• The Individual Guidance Cues Promoting Reinnervation of Original Targets are Still Unknown
• Conclusion
• Outline of the Clinical Problem
• Questions Still Open
• Methodological Approach
• Materials and Methods
• First Set of Experiments: Attempts to Reduce Collateral Axonal Branching by Alterations of the Trigeminal Input to the Facial Perikarya
• Second Set of Experiments: Attempts to Reduce Collateral Axonal Branching at the Lesion Site
• Results
• First Set of Experiments: Influence of the Altered Afferent Input to Axotomized Facial Perikarya on the Quality of Reinnervation
• Second set of Experiments: Attempts to Reduce Collateral Axonal Branching at the Lesion Site
• Discussion
• The Combined Approach to Evaluate the Quality of Peripheral Nerve Regeneration
• Sensory-Motor Integrity as A Factor for Motor Regeneration
• Collateral Branching Versus Terminal Sprouting of Axons
• Prospects for the Future
• References
• Subject index.