The Myc/Max/Mad Transcription Factor Network

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Eisenman, R. N. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2006.
• Σειρά: Current Topics in Microbiology and Immunology, 302
• Θέματα: Medicine.; Human genetics.; Medical microbiology.; Biomedicine.; Medical Microbiology.; Human Genetics.

Intense study of the enigmatic myc proto-oncogene over the last 20 years has broadened our view of its functions and led to insights into transcriptional regulation as well as cancer etiology, cell proliferation, apoptosis, and organismal development. How can one gene be involved in so many aspects...

Πίνακας περιεχομένων:

• Making Myc
• Transcriptional Activation by the Myc Oncoprotein
• Mechanisms of Transcriptional Repression by Myc
• The Mad Side of the Max Network: Antagonizing the Function of Myc and More
• Structural Aspects of Interactions Within the Myc/Max/Mad Network
• Myc Target Transcriptomes
• c-Myc, Genome Instability, and Tumorigenesis: The Devil Is in the Details
• Lessons Learned from Myc/Max/Mad Knockout Mice
• Myc/Max/Mad in Invertebrates: The Evolution of the Max Network
• The Mlx Network: Evidence for a Parallel Max-Like Transcriptional Network That Regulates Energy Metabolism.