Tumor Angiogenesis Basic Mechanisms and Cancer Therapy /

Preface Tumor development and progression occur as a result of cumulative acquisition of genetic alterations affecting oncogenes and tumor suppressor genes. As a consequence of these alterations the arising tumor gains some fatal properties such as increased cell proliferation and decreased apoptosi...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Marmé, Dieter (Επιμελητής έκδοσης), Fusenig, Norbert (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2008.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
Πίνακας περιεχομένων:
  • Historical Overview
  • Tumor Angiogenesis: from Bench to Bedside
  • Mechanisms
  • Vasculogenesis and Angiogenesis in Development
  • Guidance of Vascular and Neuronal Network Formation
  • The Angiogenic Switch in Tumorigenesis
  • Pathophysiology and Clinical Implications of Vascular Endothelial Growth Factor
  • Regulation of Angiogenesis and Vascular Homeostasis Through the Angiopoietin / Tie System
  • Eph Receptors and Ephrins: Role in Vascular Development and Tumor Angiogenesis
  • The Role of the Neuropilins and Their Associated Plexin Receptors in Tumor Angiogenesis and Tumor Progression
  • Platelet-derived Growth Factor: Impact on Physiological and Tumor Angiogenesis
  • Hypoxia and Tumour Angiogenesis
  • Hypoxia and Angiogenesis in Glioblastomas
  • Endogenous Inhibitors of Angiogenesis
  • Thrombospondins and Angiogenesis
  • Molecular and Cellular Aspects of Heparanase
  • Vessel Maturation and Perivascular Cells
  • Adhesion Molecules in the Vascular Cell Cross-Talk
  • Homing and Differentiation of Endothelial Progenitor Cells
  • Molecular Players in Lymphangiogenesis
  • The Relationship Between Tumors and the Lymphatics: Consequences for Metastasis
  • Inflammation and Angiogenesis: Innate Immune Cells as Modulators of Tumor Vascularization
  • Arteriovenous Malformation in Mice and Men
  • Animal Models and Preclinical Anti-Angiogenic Studies
  • Vascular Endothelial Growth Factor Antibodies for Anti-Angiogenic Therapy
  • Vascular Endothelial Growth Factor
  • Vascular Endothelial Growth Factor Receptor Antibodies for Anti-Angiogenic Therapy
  • Angiopoietin-2 Antagonists for Anti-Angiogenic Therapy
  • Anti-Angiogenic Therapy with Thrombospondins
  • The Use of Orthotopic Models to Validate Antivascular Therapies for Cancer
  • Vascular Tumor Targeting
  • Molecular Imaging of Targets and Therapeutics in Tumour Angiogenesis
  • Imaging of Tumor Angiogenesis and Antiangiogenesis
  • Visualization of Microcirculation and Anti-Angiogenic Tumor Therapy
  • Cellular Actions of Angiogenesis Inhibitors on Blood Vessels
  • Antiangiogenic Therapy for Normalization of Tumor Vasculature and Microenvironment
  • Metronomic Antiangiogenic Chemotherapy: Questions and Answers
  • Anti-Angiogenic Tumor Therapy in Clinical Studies
  • The Development of Avastin
  • Clinical Development of Sorafenib (BAY 43–9006) VEGFR and RAF Inhibitor
  • Clinical Development of the VEGFR Signalling Inhibitor AZD2171
  • Clinical Development of Sunitinib Malate
  • The EGF(R) and VEGF(R) Pathways as Combined Targets for Anti-Angiogenesis Trials in Cancer Therapy
  • Imaging the Effect of Anti-Angiogenic Tumor Therapy in Clinical Studies
  • Vandetanib (ZACTIMA™; ZD6474): Preclinical and Clinical Development
  • Integrins: Targets for Anti-Angiogenic Therapy
  • Thalidomide in Multiple Myeloma
  • Surrogate Markers of Angiogenesis
  • Vascular Disrupting Agents in Cancer Therapy.