Insights into Receptor Function and New Drug Development Targets

G-Protein Coupled receptors (GPCRs) and other receptors are significant targets for drug discovery, due to their roles in fundamental physiological processes. Among these roles are: regulation of growth, food intake, reproduction, water balance, sensory perception, blood pressure and heart rate. GPC...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Conn, Michael (Επιμελητής έκδοσης), Kordon, Claude (Επιμελητής έκδοσης), Christen, Yves (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2006.
Σειρά:Research and Perspectives in Endocrine Interactions
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
Πίνακας περιεχομένων:
  • Molecular and functional diversity of the TRPC family of ion channels. TRPC channels and their role in ROCE/SOCE
  • Functional Rescue of Misfolded Receptor Mutants
  • Obesity-related mutations of leptin and melanocortin receptors
  • cAMP- and cGMP-dependent control of lipolysis and lipid mobilization in humans: putative targets for fat cell management
  • Central Neuropeptide Receptors Involved in Water Balance: Application to Apelin
  • Targeting regulators of G protein signaling (RGS proteins) to enhance agonist specificity
  • Dimeric GPCRs: what did we learn from the metabotropic glutamate receptors?
  • Guiding principles applied in the design of GPCR-selective hypothalamic hormone agonists and antagonists
  • Mutations in G proteins and G protein-coupled receptors in human endocrine diseases
  • A molecular dissection of the glycoprotein hormone receptors
  • Receptor Tyrosine Kinases as Targets for Cancer Therapy Development
  • Targets for pituitary tumor therapy
  • The endogenous cannabinoid system in the control of food intake and energy balance.