Alternative Splicing and Disease

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Jeanteur, Philippe (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2006.
• Σειρά: Progress in Molecular and Subcellular Biology, 44
• Θέματα: Life sciences.; Molecular biology.; Biochemistry.; Cell biology.; Life Sciences.; Cell Biology.; Molecular Medicine.; Biochemistry, general.

Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative...

Πίνακας περιεχομένων:

• Methods and Platforms for the Quantification of Splice Variants' Expression
• Pre-mRNA Missplicing as a Cause of Human Disease
• Alternative Splicing: Therapeutic Target and Tool
• SR Proteins as Potential Targets for Therapy
• Misregulation of Tau Alternative Splicing in Neurodegeneration and Dementia
• Spinal Muscular Atrophy and Therapeutic Prospects
• Misregulation of Alternative Splicing Causes Pathogenesis in Myotonic Dystrophy
• Redirecting Splicing to Address Dystrophin Mutations: Molecular By-pass Surgery
• Altered Splicing in Prelamin A-Associated Premature Aging Phenotypes
• Splicing Modulation as a Modifier of the CFTR Function.