Conditional Mutagenesis: An Approach to Disease Models

• Corporate Author: SpringerLink (Online service)
• Other Authors: Feil, Robert (Editor), Metzger, Daniel (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2007.
• Series: Handbook of Experimental Pharmacology, 178
• Subjects: Medicine.; Human genetics.; Molecular biology.; Pharmacology.; Medical biochemistry.; Biomedicine.; Pharmacology/Toxicology.; Molecular Medicine.; Human Genetics.; Medical Biochemistry.
• Physical Description: XII, 532 p. online resource.
• ISBN: 9783540351092
• ISSN: 0171-2004 ;

Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.