Organolithiums in Enantioselective Synthesis

• Corporate Author: SpringerLink (Online service)
• Other Authors: Hodgson, David M. (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2003.
• Edition: 1st ed. 2003.
• Series: Topics in Organometallic Chemistry, 5
• Subjects: Organometallic chemistry .; Inorganic chemistry.; Medicinal chemistry.; Organometallic Chemistry.; Inorganic Chemistry.; Medicinal Chemistry.

Organolithium chemistry occupies a central position in the selective construction of C-C bonds in both simple and complex molecules. Paralleling the surge of interest in methods for asymmetric synthesis, the use of organolithiums in enantioselective synthesis has witnessed spectacular advances in a...

Table of Contents:

• Overview of Organolithium-Ligand Combinations and Lithium Amides for Enantioselective Processes
• Enantioselective Addition of Organolithiums to C=O Groups and Ethers
• Enantioselective Conjugate Addition and 1,2-Addition to C=N of Organolithium Reagents
• Enantioselective Synthesis by Lithiation Adjacent to Oxygen and Electrophile Incorporation
• Enantioselective Synthesis by Lithiation Adjacent to Nitrogen and Electrophile Incorporation
• Enantioselective Synthesis by Lithiation Adjacent to Sulfur, Selenium or Phosphorus, or without an Adjacent Activating Heteroatom
• Enantioselective Synthesis by Lithiation Adjacent to Oxygen and Subsequent Rearrangement
• Enantioselective Synthesis by Lithiation to Generate Planar or Axial Chirality
• Enantioselective Carbolithiations.