Left-Right Asymmetry in Vertebrate Development

Externally the vertebrate body plan presents a bilateral symmetry in relation to the midline. However, inside the body the distribution of the visceral organs follows a very particular pattern that is not symmetrical in relation to the midline. The last 10 years have seen remarkable advances in our...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: López-Gracia, Maria L. (Συγγραφέας), Ros, Marian (Συγγραφέας)
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2007.
Σειρά:Advances in Anatomy Embryology and Cell Biology, 188
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
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100 1 |a López-Gracia, Maria L.  |e author. 
245 1 0 |a Left-Right Asymmetry in Vertebrate Development  |h [electronic resource] /  |c by Maria L. López-Gracia, Marian Ros. 
264 1 |a Berlin, Heidelberg :  |b Springer Berlin Heidelberg,  |c 2007. 
300 |a XII, 126 p. 16 illus., 13 illus. in color.  |b online resource. 
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490 1 |a Advances in Anatomy Embryology and Cell Biology,  |x 0301-5556 ;  |v 188 
505 0 |a Establishment of Left-Right Asymmetry -- Signaling Pathways with a Predominant Role in Left-Right Patterning -- Mouse Models of Laterality -- Genetics of Human Alterations of Organ Situs -- Concluding Remarks. 
520 |a Externally the vertebrate body plan presents a bilateral symmetry in relation to the midline. However, inside the body the distribution of the visceral organs follows a very particular pattern that is not symmetrical in relation to the midline. The last 10 years have seen remarkable advances in our understanding of how the internal asymmetries typical of the vertebrate body are established and controlled. The use of different development models has permitted to uncover fascinating ways of creating asymmetry, like the activity of the nodal cilia. A host of studies has also unravelled the involvement of many genes in the left right patterning pathway. Based on this knowledge the genetic basis of human laterality defects are beginning to be revealed. It is a major challenge now to understand how all these genes control left right development as well as the complex set of interactions established between them. 
650 0 |a Medicine. 
650 0 |a Human physiology. 
650 1 4 |a Biomedicine. 
650 2 4 |a Human Physiology. 
700 1 |a Ros, Marian.  |e author. 
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776 0 8 |i Printed edition:  |z 9783540363477 
830 0 |a Advances in Anatomy Embryology and Cell Biology,  |x 0301-5556 ;  |v 188 
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