The Histone Code and Beyond New Approaches to Cancer Therapy /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Berger, S. L. (Editor), Nakanishi, O. (Editor), Haendler, B. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2006.
• Series: Ernst Schering Research Foundation Workshop, 57
• Subjects: Life sciences.; Oncology.; Biochemistry.; Cell biology.; Life Sciences.; Biochemistry, general.; Cell Biology.

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expre...

Table of Contents:

• The Role of Histone Modifications in Epigenetic Transitions During Normal and Perturbed Development
• Nucleosome Structure and Function
• The Role of Snf2-Related Proteins in Cancer
• Imitation Switch Complexes
• How Is Epigenetic Information on Chromatin Inherited After DNA Replication?
• Polycomb Silencing Mechanisms and Genomic Programming
• CpG Island Methylation and Histone Modifications: Biology and Clinical Significance
• Histone Post-Translational Modifications Regulate Transcription and Silent Chromatin in Saccharomyces cerevisiae
• Histone Acetylation-Mediated Chromatin Compaction During Mouse Spermatogenesis
• Role of Ubiquitin-Like Proteins in Transcriptional Regulation
• Interplay of the SUMO and MAP Kinase Pathways.